Francisella DnaK Inhibits Tissue-nonspecific Alkaline Phosphatase
نویسندگان
چکیده
منابع مشابه
Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase.
Following pulmonary infection with Francisella tularensis, we observed an unexpected but significant reduction of alkaline phosphatase, an enzyme normally up-regulated following inflammation. However, no reduction was observed in mice infected with a closely related gram-negative pneumonic organism (Klebsiella pneumoniae) suggesting the inhibition may be Francisella-specific. In similar fashion...
متن کاملRunning title: Alkaline phosphatase inhibition and Francisella survival 1 Francisella DnaK Inhibits Tissue Nonspecific Alkaline Phosphatase
Following pulmonary infection with Francisella tularensis, we observed an unexpected but significant reduction of alkaline phosphatase, an enzyme normally up-regulated following inflammation. However, no reduction was observed in mice infected with a closely related Gram negative pneumonic organism (Klebsiella pneumonia) suggesting the inhibition may be Francisella specific. In similar fashion ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.404400